The Sister City relationship between Springfield and Tlaquepaque, Jalisco, Mexico was formalized on June 27, 2003. Both cities work with the International Sister Cities Association.
Based on an earlier fact-finding visit to Tlaquepaque, the Springfield Sister Cities Association found a number of compatibilities with that city such as mutual interest in tourism, culture, the arts, education, and commercial growth and development.
The SSCA has sought this relationship with a Spanish-speaking community because of the growth of the Hispanic population in the Ozarks region and for the opportunities for business and cultural development.